p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase/Akt pathway is required for Zn -induced cyclooxygenase-2 expression
نویسندگان
چکیده
Weidong Wu, Robert A. Silbajoris, Young E. Whang, Lee M. Graves, Philip A. Bromberg, and James M. Samet Division of Immunology and Infectious Disease, Department of Pediatrics, Center for Environmental Medicine, Asthma, and Lung Biology, Department of Medicine and Lineberger Comprehensive Cancer Center, and Department of Pharmacology, University of North Carolina, Chapel Hill; and Human Studies Division, National Health Effects and Environmental Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina
منابع مشابه
p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression.
Cyclooxygenase 2 (COX-2) expression is induced by physiological and inflammatory stimuli. Regulation of COX-2 expression is stimulus and cell type specific. Exposure to Zn2+ has been associated with activation of multiple intracellular signaling pathways as well as the induction of COX-2 expression. This study aims to elucidate the role of intracellular signaling pathways in Zn2+-induced COX-2 ...
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